Accelerating the development of vaccine microarray patches for epidemic response and equitable immunization coverage requires investment in microarray patch manufacturing facilities.
Scarnà Tiziana, Menozzi-Arnaud Marion, Friede Martin, DeMarco Kerry, Plopper George, Hamer Melinda, Chakrabarti Ajoy, Gilbert Philippe Alexandre, Jarrahian Courtney, Mistilis Jessica, Hesselink Renske, Gandrup-Marino Kristoffer, Amorij Jean-Pierre, Giersing Birgitte
Expert opinion on drug delivery · 2023 · PMID 36649573 · 인용 12
INTRODUCTION: There is a need for investment in manufacturing for vaccine microarray patches (vMAPs) to accelerate vMAP development and access. vMAPs could transform vaccines deployment and reach to everyone, everywhere.
AREAS COVERED: We outline vMAPs' potential benefits for epidemic preparedness and for outreach in low- and lower-middle-income countries (LMICs), share lessons learned from pandemic response, and highlight that investment in manufacturing-at-risk could accelerate vMAP development.
EXPERT OPINION: Pilot manufacturing capabilities are needed to produce clinical trial material and enable emergency response. Funding vMAP manufacturing scale-up in parallel to clinical proof-of-concept studies could accelerate vMAP approval and availability. Incentives could mitigate the risks of establishing multi-vMAP manufacturing facilities early.