Lack of association between loneliness, social isolation and inflammation in people living with HIV aged ≥50 years: Results from the sub-study "No One Alone-Gesida Study".
Blanco Jose-Ramon, Albendin-Iglesias Helena, Negredo-Puigmal Eugenia, Barrios-Blandino Ana Mª, Tomás-Jimenez Cristina, Sanjoaquin-Conde Isabel, Saumoy María, Pérez-Esquerdo Verónica, Gonzalez-Cuello Inmaculada, López-Lirola Ana María, Galindo María José, Cabello-Clotet Noemí, Otero Jesica Abadía, Merino-Muñoz Dolores, Cano-Smith Joanna, Muelas-Fernandez Magdalena, De La Torre Javier, González-Baeza Alicia, Romero Lourdes, Ocampo Antonio, Torres Rafael, Hidalgo Carmen, Esteban Herminia, Fernandes-López Maria Angeles, Puig Jordi, Fraile Lucio Garcia, Morell Enrique Bernal, Perez-Martinez Laura, Montero Marta De Miguel, Jarrin Inma, Olalla Julian, GESIDA 12021 STUDY GROUP
PloS one · 2025 · PMID 41406145
Inflammation is linked to multiple health conditions. Emerging evidence suggest it may play a role in the association between social isolation - loneliness and health outcomes. People living with HIV (PLWH) exhibit chronic inflammation even with viral suppression, likely due to ongoing immune activation.
However, few studies have explored inflammatory biomarker in PLWH experiencing loneliness or social isolation. This study aimed to assess this association in PLWH aged 50 or older.